ea0044p196 | Obesity and Metabolism | SFEBES2016
Norton Mariana
, Alamshah Amin
, Spreckley Eleanor
, Kinsey-Jones James S.
, Amin Anjali
, Li Fanyi
, Canisius Ishani
, Johnson Rebecca
, Akalestou Elina
, Malik Zainab
, Bloom Stephen R.
, Murphy Kevin G.
High protein diets suppress appetite, but are difficult to adhere to. Understanding how the gut senses protein may identify mechanisms to drive satiety. Amino acid products of protein digestion are thought to be sensed by G protein coupled receptors in the gut, including the calcium sensing receptor (CaSR). Calcium ions are the major ligand of the CaSR, but aromatic amino acids, particularly L-phenylalanine (L-Phe), allosterically modulate CaSR activity....